Circadian rhythms, time-restricted feeding, and healthy aging

Circadian rhythms, time-restricted feeding, and healthy aging.

Circadian rhythms optimize physiology and health by temporally coordinating cellular function, tissue function, and behavior. These endogenous rhythms dampen with age and thus compromise temporal coordination. Feeding-fasting patterns are an external cue that profoundly influence the robustness of daily biological rhythms. Erratic eating patterns can disrupt the temporal coordination of metabol...

Exploring Links between Circadian Rhythms and Healthy Aging

Circadian rhythms: PASsing time

Links are being discovered between the circadian clock mechanisms in different species. The Neurospora Frequency protein has a rhythm of abundance and phosphorylation similar to that of the Drosophila Period protein, and Neurospora and mouse clock components, like Period, have 'PAS' domains.

Effect of feeding regimens on circadian rhythms: Implications for aging and longevity

Increased longevity and improved health can be achieved in mammals by two feeding regimens, caloric restriction (CR), which limits the amount of daily calorie intake, and intermittent fasting (IF), which allows the food to be available ad libitum every other day. The precise mechanisms mediating these beneficial effects are still unresolved. Resetting the circadian clock is another intervention...

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is therefore highly relevant in the context of circadian biology, but its characterization on the proteome-wide scale and its circadian clock dep...